Brand name: allopurinol
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The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. Nervous systemNervous system side effects have been reported extremely rarely and included case reports of peripheral neuropathy, catatonia, and cerebral vasculitis associated with allopurinol hypersensitivity. MetabolicKrasinger and colleagues suggest that it may be reasonable to add allopurinol to the pancreatic enzyme treatment regimen in CF patients that have a urine pH of less than 6 and also excrete large amounts of uric acid. Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine to approximately 1/3 to 1/4 the usual dose. Eleven days later (approximately 7 weeks after allopurinol was discontinued), both the hemoglobin level and reticulocyte count began to rise. DermatologicAllopurinol-induced rash may be followed by more severe hypersensitivity reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, vasculitis, nephrotoxicity, and hepatotoxicity. See the package inserts or Acetazolamide in Carbonic Anhydrase Inhibitors (Systemic) , Allopurinol (Systemic) , and/or Potassium Citrate in Citrates (Systemic) for specific dosing guidelines for use of these products. Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of gout (average 6% in early studies).

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